Many scientists, however, say there is no evidence that Blue Monday causes any more sadness than other specific days of the year. 28 , the idea of Blue Monday persists.
答案：(B) And yet
語意轉折：「然而，儘管沒有證據，憂鬱星期一的概念依然存在」，And yet（然而）符合這個轉折；If so（如果是這樣）、On that、With this 都不合。
這一格要填的是句首的轉承語，四個選項看起來都像「可以放句首」的組合，於是你可能只憑語感挑。這裡有一個很實用的檢查法：能單獨放在句首、後面直接加逗號的轉承語，本身必須是完整的；如果它是「介系詞＋代名詞」，後面通常還要再接名詞才完整。
先看前後兩句的邏輯。前一句：Many scientists, however, say there is no evidence that Blue Monday causes any more sadness...（許多科學家說，沒有證據顯示憂鬱星期一比其他日子更令人難過）。本句：___ , the idea of Blue Monday persists（___，憂鬱星期一的說法依然存在）。「科學上站不住腳」對上「大家還是照信不誤」——這是明確的轉折，而且帶著一點「居然如此」的意味，這正是 And yet（然而、儘管如此）的語氣。 persists（持續存在）這個動詞本身也含有「不該存在卻還在」的暗示。
If so（如果是這樣）需要前一句提供一個條件或假設，但前一句是斷定的事實，不是假設；On that 和 With this 都不是能單獨使用的轉承語——它們後面必須再接名詞才完整，例如 on that point（就那一點而言）、with this in mind（把這一點記在心上）。光憑「後面接不接得下去」就能刪掉這兩個。
and yet（然而、儘管如此）、yet（然而，可單獨當連接詞）、if so（如果是這樣）、with this in mind（把這一點記在心上）、on that point（就那一點而言）、persist（持續存在）。
The idea of Blue Monday dates back to a 2005 campaign by Sky Travel. The travel company wanted to 26 people to take January vacations, so they reached out to a psychologist. The scholar then developed an equation to find the most depressing day of the year, and it turned out to be the third Monday in January. Since then, other companies have jumped on the bandwagon to promote everything from soft drinks to new clothes as a 27 . A group in the UK even started a website devoted to "beating Blue Monday."
Many scientists, however, say there is no evidence that Blue Monday causes any more sadness than other specific days of the year. 28 , the idea of Blue Monday persists. According to psychologist Dean Burnett, people feel down in January 29 post-holiday discontent, and the Blue Monday claim makes it seem like there are scientific reasons for this. Also, the idea 30 a very complex issue regarding depression into something simple and easily understandable, and that tends to appeal to a lot of people.